Are you looking for the ergonomic computer mouse? Do you know what to consider before buying one? Well, we’ve managed to put together a list of the best ergonomic computer mouse for your consideration. You can choose one and use it according to your needs.

In most cases, customers lack knowledge about market conditions, which leads to poor purchasing decisions. Fortunately, you have come to the right place as we will present you with a complete guide on how to select the ergonomic computer mouse for you. We have searched for hours and spent a lot of time and effort making sure you get a good return on your hard-earned money.

You can find a quick comparison and a list of the top ergonomic computer mouse below if you’re short on time.

Our Premium Picks!

EDITOR’S CHOICE
9.9
Anker 2.4G Wireless Vertical Ergonomic Optical Mouse, 800 / 1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, Macbook – Black

Anker 2.4G Wireless Vertical Ergonomic Optical Mouse, 800 / 1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, Macbook - Black

PREMIUM PICK
9.4
Amazon Basics Ergonomic Wireless PC Mouse – DPI adjustable – Black

Amazon Basics Ergonomic Wireless PC Mouse - DPI adjustable - Black

PREMIUM CHOICE
9.2
Ergonomic Mouse Wireless Mice,2.4G Computer Cordlees Mouse 6 Buttons 3 Adjustable DPI 800/1200/1600 Levels,Vertical Mouse for PC,Desktop,Laptop

Ergonomic Mouse Wireless Mice,2.4G Computer Cordlees Mouse 6 Buttons 3 Adjustable DPI 800/1200/1600 Levels,Vertical Mouse for PC,Desktop,Laptop

Best ergonomic computer mouse

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EDITOR’S CHOICE

Anker 2.4G Wireless Vertical Ergonomic Optical Mouse, 800 / 1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, Macbook - Black

Anker 2.4G Wireless Vertical Ergonomic Optical Mouse, 800 / 1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, Macbook – Black
9.8
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PREMIUM PICK

Amazon Basics Ergonomic Wireless PC Mouse - DPI adjustable - Black

Amazon Basics Ergonomic Wireless PC Mouse – DPI adjustable – Black
9.5
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PREMIUM CHOICE

Ergonomic Mouse Wireless Mice,2.4G Computer Cordlees Mouse 6 Buttons 3 Adjustable DPI 800/1200/1600 Levels,Vertical Mouse for PC,Desktop,Laptop

Ergonomic Mouse Wireless Mice,2.4G Computer Cordlees Mouse 6 Buttons 3 Adjustable DPI 800/1200/1600 Levels,Vertical Mouse for PC,Desktop,Laptop
9.2
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Logitech MX Vertical Wireless Mouse – Advanced Ergonomic Design Reduces Muscle Strain, Control and Move Content Between 3 Windows and Apple Computers (Bluetooth or USB), Rechargeable, Graphite Logitech MX Vertical Wireless Mouse – Advanced Ergonomic Design Reduces Muscle Strain, Control and Move Content Between 3 Windows and Apple Computers (Bluetooth or USB), Rechargeable, Graphite
8.9
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Logitech ERGO M575 Wireless Trackball Mouse - Easy thumb control, precision and smooth tracking, ergonomic comfort design, for Windows, PC and Mac with Bluetooth and USB capabilities - Graphite Logitech ERGO M575 Wireless Trackball Mouse – Easy thumb control, precision and smooth tracking, ergonomic comfort design, for Windows, PC and Mac with Bluetooth and USB capabilities – Graphite
8.4
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Redragon M602 RGB Wired Gaming Mouse RGB Spectrum Backlit Ergonomic Mouse Griffin Programmable with 7 Backlight Modes up to 7200 DPI for Windows PC Gamers (Black) Logitech ERGO M575 Wireless Trackball Mouse – Easy thumb control, precision and smooth tracking, ergonomic comfort design, for Windows, PC and Mac with Bluetooth and USB capabilities – Graphite
8.1
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Amazon Basics Full-Size Ergonomic Wireless PC Mouse with Fast Scrolling Amazon Basics Full-Size Ergonomic Wireless PC Mouse with Fast Scrolling
7.6
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Logitech M525 Wireless Mouse – Long 3 Year Battery Life, Ergonomic Shape for Right or Left Hand Use, Micro-Precision Scroll Wheel, and USB Unifying Receiver for Computers and Laptops, Black/Gray Logitech M525 Wireless Mouse – Long 3 Year Battery Life, Ergonomic Shape for Right or Left Hand Use, Micro-Precision Scroll Wheel, and USB Unifying Receiver for Computers and Laptops, Black/Gray
7.5
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Logitech MX Master 2S Wireless Mouse – Use on Any Surface, Hyper-Fast Scrolling, Ergonomic Shape, Rechargeable, Control Upto 3 Apple Mac and Windows Computers, Graphite (Discontinued by Manufacturer) Logitech MX Master 2S Wireless Mouse – Use on Any Surface, Hyper-Fast Scrolling, Ergonomic Shape, Rechargeable, Control Upto 3 Apple Mac and Windows Computers, Graphite (Discontinued by Manufacturer)
7.2
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J-Tech Digital Ergonomic Mouse Wired - RGB Vertical Gaming Mouse with 5 Adjustable DPI Settings up to 4000 DPI, Computer Mouse for Carpal Tunnel, Removable Palm Rest and Thumb Buttons [V628R] J-Tech Digital Ergonomic Mouse Wired – RGB Vertical Gaming Mouse with 5 Adjustable DPI Settings up to 4000 DPI, Computer Mouse for Carpal Tunnel, Removable Palm Rest and Thumb Buttons [V628R]
6.9
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Anker 2.4G Wireless Vertical Ergonomic Optical Mouse, 800 / 1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, Macbook – Black

EDITOR’S CHOICE

Specifications:

Anker 2.4G Wireless Vertical Ergonomic Optical Mouse, 800 / 1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, Macbook - Black

$35.99  in stock
Amazon.com
as of May 25, 2022 1:34 pm

Features

  • Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain.
  • 800 / 1200 / 1600 DPI Resolution Optical Tracking Technology provides more sensitivity than standard optical mice for smooth and precise tracking on a wide range of surfaces.
  • Added next/previous buttons provide convenience when webpage browsing; the superior choice for internet surfers, gamers and people who work at length at the computer.
  • Enters power saving mode (power is cut off completely) after 8 minutes idle, press right or left button for it to wake. Product dimensions: 120*62.8*74.8 mm; product weight: 3.4 oz.
  • Package includes: 1 Anker Wireless Vertical Ergonomic Optical Mouse (2 AAA batteries not included), 1 2.4G USB receiver (in the bottom of the mouse), 1 instruction manual. 18-month hassle-free warranty.

Amazon Basics Ergonomic Wireless PC Mouse – DPI adjustable – Black

PREMIUM PICK

Specifications:

Amazon Basics Ergonomic Wireless PC Mouse - DPI adjustable - Black

$9.76  in stock
15 used from $8.59
Free shipping
Amazon.com
as of May 25, 2022 1:34 pm

Features

  • Compact wireless mouse with adjustable DPI for preferred sensitivity (600, 1000, 1600, 2400, or 3600 DPI)
  • Advanced optical sensor; works on most surfaces; clickable metallic scroll wheel; back/forward thumb buttons for easily navigating web pages
  • 2.4 GHz wireless connection (does not support Bluetooth) with a 33-foot range; uses AES-128 encryption for added security; this mouse uses a small USB receiver that can stay plugged into your computer without obstructing other ports
  • Ergonomic shape with rubberized sides ensures a comfortable hold; compatible with Windows 7, 8, and 10; uses 1 AA battery (included); sleek Black color
  • Measures 4.1 by 2.9 by 1.5 inches; backed by an Amazon Basics 1-year limited warranty

Ergonomic Mouse Wireless Mice,2.4G Computer Cordlees Mouse 6 Buttons 3 Adjustable DPI 800/1200/1600 Levels,Vertical Mouse for PC,Desktop,Laptop

PREMIUM CHOICE

Specifications:

Ergonomic Mouse Wireless Mice,2.4G Computer Cordlees Mouse 6 Buttons 3 Adjustable DPI 800/1200/1600 Levels,Vertical Mouse for PC,Desktop,Laptop

$23.90  in stock
2 new from $23.90
Free shipping
Amazon.com
as of May 25, 2022 1:34 pm

Features

  • Ergonomic Design make your hand more healthier and less overall strain. Widely compatible with Windows 2000/ XP/Vist /7/8/10/Linux.Easy to Use-USB receiver at the bottom of mouse and need battery. Power saving mode after 8 minutes idle
  • Stable connection with less noise click-reliable 2.4G wireless mouse connection with high performance with 33ft.Quieter click makes you concentrate on work without disturbing others.
  • Vertical Ergonomic Mouse easily adjusts the DPI of the mouse. 800/1200/1600 DPI Resolution Optical tracking on a wide range of surfaces and more precise.
  • Six buttons is a nice choice for computer mouse, gamers and other network activity.Especially the "Page Back" and "Page Forward" functionality.
  • Excellent Service for your satisfied, If you have any questions for our ergonomic vertical mouse,Please feel free to contact us for Replacement or Refund.Hope you have a pleasure purchase.

Logitech MX Vertical Wireless Mouse – Advanced Ergonomic Design Reduces Muscle Strain, Control and Move Content Between 3 Windows and Apple Computers (Bluetooth or USB), Rechargeable, Graphite

Specifications:

Logitech MX Vertical Wireless Mouse – Advanced Ergonomic Design Reduces Muscle Strain, Control and Move Content Between 3 Windows and Apple Computers (Bluetooth or USB), Rechargeable, Graphite

$98.99  in stock
5 new from $98.79
Free shipping
Amazon.com
as of May 25, 2022 1:34 pm

Features

  • ADVANCED ERGONOMIC DESIGN - Places your hand in a natural handshake position using a unique 57-degree angle, preventing forearm twisting and reducing muscular strain by 10 percent (As compared with a traditional non-vertical mouse. Based on Logitech Study, September 2017)
  • HYPER-EFFICIENT TRACKING - 4000 DPI high-precision sensor provides precise tracking that requires 4x less hand movement compared to a traditional mouse with a 1000 DPI sensor
  • CROSS-COMPUTER CONTROL - Game-changing capacity to navigate seamlessly on three computers, and copy-paste text, images, and files from one to the other using Logitech FLOW
  • THREE WAYS TO CONNECT - Use with up to three Windows or Mac computers via included wireless USB unifying receiver or Bluetooth smart technology or the included USB-C charging cable
  • RECHARGEABLE BATTERY - With quick charging: Stays powered for 4 months on a full charge – and get 3 hours of use from a 1-minute quick charge (Battery life may vary based on user and computing conditions)

Logitech ERGO M575 Wireless Trackball Mouse – Easy thumb control, precision and smooth tracking, ergonomic comfort design, for Windows, PC and Mac with Bluetooth and USB capabilities – Graphite

Specifications:

Logitech ERGO M575 Wireless Trackball Mouse - Easy thumb control, precision and smooth tracking, ergonomic comfort design, for Windows, PC and Mac with Bluetooth and USB capabilities - Graphite

$49.99  in stock
Amazon.com
as of May 25, 2022 1:34 pm

Features

  • Ergonomic comfort design, relaxed hand and arm: The comfortable, sculpted ergonomic shape naturally fits your hand.
  • Smooth thumb control, precise tracking: Great cursor control on any surface. Adjust the cursor speed with Logitech Options software.
  • Perfect for tight workspaces: Because the trackball doesn’t move, it’s perfect for tight workspaces and busy desks.
  • 2 ways to connect and multi-OS: Connect simply with Bluetooth or the USB receiver and never worry about drop-offs or lag up to a 33 ft (10m) range. Nominal value: 400 dpi
  • Plastic parts in ERGO M575 include post consumer recycled plastic (Graphite/Black: 50%, Off-White: 21%). Uses FSC-certified paper for responsible packaging.

Redragon M602 RGB Wired Gaming Mouse RGB Spectrum Backlit Ergonomic Mouse Griffin Programmable with 7 Backlight Modes up to 7200 DPI for Windows PC Gamers (Black)

Specifications:

Redragon M602 RGB Wired Gaming Mouse RGB Spectrum Backlit Ergonomic Mouse Griffin Programmable with 7 Backlight Modes up to 7200 DPI for Windows PC Gamers (Black)

$17.99
$14.44
 in stock
Amazon.com
as of May 25, 2022 1:34 pm

Features

  • WIRED GAMING MOUSE; built for Gaming Computers - Ergonomic Redragon M602-RGB “Griffin” RGB Backlit Gaming PC Mouse up to 7200 DPI (user adjustable 800/1200/1600/2400/7200 DPI), 10G acceleration. The High-Precision Sensor delivers Pinpoint Accuracy while the Gaming Grade Micro Switches ensure longevity, greater durability and extreme responsiveness, giving you an even greater edge over your competition
  • RGB BACKLIT MMO PROGRAMMABLE PC GAMING MOUSE; 7 MMO user programmable buttons, 5 Memory Profiles each with distinct LED color option for quick identification. 7 different backlight modes. (Backlight can be disabled) The Redragon M602-RGB Gaming Mouse offers you total personalization for your Gaming Computer and Gaming Laptop
  • ERGONOMIC GAMER MOUSE; Delivering an extremely comfortable and precise experience for Computer Games. The ergonomic shape of the Redragon M602-RGB PC Gaming Mouse is built for comfort, fits naturally in your hand, the buttons are tuned to reduce click fatigue
  • HIGH-END PC GAMING MOUSE FEATURES; The Redragon M602-RGB Mouse features; Built-in Weight Tuning for the right balance, Anti-Skid Scroll Wheel, Durable smooth TEFLON feet pads for ultimate gaming control. 7 programmable buttons. Total 8 buttons. The Mouse works great with Redragon Gaming Mousepads & Keyboards. Comes with 6 foot, 3mm strong high-speed braided fiber cable and a gold-plated corrosion free USB connector for a reliable connection
  • PC GAMING MOUSE COMPATIBILITY: Windows 10, Windows 8, Windows 7, Windows Vista, or Windows XP, Limited Mac OS support Works well with all major Gaming Computers Brands and Gaming Laptops

Amazon Basics Full-Size Ergonomic Wireless PC Mouse with Fast Scrolling

Specifications:

Amazon Basics Full-Size Ergonomic Wireless PC Mouse with Fast Scrolling

$28.22  in stock
14 used from $16.49
Free shipping
Amazon.com
as of May 25, 2022 1:34 pm

Features

  • Full-size wireless mouse with fast-scrolling, clickable wheel and forward/back thumb buttons for fast, easy navigating through large documents and web pages
  • Ergonomically designed for right-handed users; smooth, gently curved profile fits perfectly in the palm of the hand for enhanced comfort
  • 2.4 GHz (non-bluetooth) wireless connection; uses a small USB receiver that can stay plugged into your computer without obstructing other ports
  • Optical sensor (1600 DPI resolution) works on most surfaces; uses 2 AA batteries (included); battery LED light and on/off switch for extended battery life
  • Compatible with Windows 7, 8, and 10; backed by an Amazon Basics 1-year limited warranty

Logitech M525 Wireless Mouse – Long 3 Year Battery Life, Ergonomic Shape for Right or Left Hand Use, Micro-Precision Scroll Wheel, and USB Unifying Receiver for Computers and Laptops, Black/Gray

Specifications:

Logitech M525 Wireless Mouse – Long 3 Year Battery Life, Ergonomic Shape for Right or Left Hand Use, Micro-Precision Scroll Wheel, and USB Unifying Receiver for Computers and Laptops, Black/Gray

$39.99
$19.99
 in stock
43 new from $15.33
1 used from $39.99
Free shipping
Amazon.com
as of May 25, 2022 1:34 pm

Features

  • ERGONOMIC SHAPE - Ergonomically shaped design and soft rubber grips conform to your hand to be naturally comfortable and the compact size makes it easy to take with you wherever you use your computer at home, at work or anywhere else, USB receiver is stored inside the mouse where the batteries are located
  • Interface: USB receiver. Mouse Dimensions (height x width x depth)-4.00 x 2.24 x 1.51 inches. Receiver Dimensions (height x width x depth)-0.57 x 0.74 x 0.24 inches
  • CONVENIENT CONTROLS - Easy-to-reach Back/Forward buttons makes moving quickly between documents or browsing your favorite Web sites a breeze
  • MICRO-PRECISE SCROLL WHEEL - With more grooves per millimeter, our new scroll wheel gives you the ultimate navigation experience
  • LONG BATTERY LIFE - 3 year battery life and smart sleep mode help you go longer between battery changes

Logitech MX Master 2S Wireless Mouse – Use on Any Surface, Hyper-Fast Scrolling, Ergonomic Shape, Rechargeable, Control Upto 3 Apple Mac and Windows Computers, Graphite (Discontinued by Manufacturer)

Specifications:

Logitech MX Master 2S Wireless Mouse – Use on Any Surface, Hyper-Fast Scrolling, Ergonomic Shape, Rechargeable, Control Upto 3 Apple Mac and Windows Computers, Graphite (Discontinued by Manufacturer)

$99.99
$70.52
 in stock
22 new from $64.91
10 used from $40.99
Amazon.com
as of May 25, 2022 1:34 pm

Features

  • Cross computer control: Game changing capacity to navigate seamlessly on 3 computers, and copy paste text, images, and files from 1 to the other using Logitech flow
  • Dual connectivity: Use with upto 3 Windows or Mac computers via included Unifying receiver or Bluetooth Smart wireless technology. Gesture button- Yes
  • Advanced ergonomic design: Perfectly sculpted, hand crafted shape supports your hand and wrist in a comfortable, natural position
  • Auto shift scrolling: Speed adaptive scroll wheel auto shifts on the fly from click to click to hyper fast scrolling
  • Rechargable battery: Upto 70 days of power on a single charge

J-Tech Digital Ergonomic Mouse Wired – RGB Vertical Gaming Mouse with 5 Adjustable DPI Settings up to 4000 DPI, Computer Mouse for Carpal Tunnel, Removable Palm Rest and Thumb Buttons [V628R]

Specifications:

J-Tech Digital Ergonomic Mouse Wired - RGB Vertical Gaming Mouse with 5 Adjustable DPI Settings up to 4000 DPI, Computer Mouse for Carpal Tunnel, Removable Palm Rest and Thumb Buttons [V628R]

$27.95
$25.94
 in stock
2 new from $25.94
Free shipping
Amazon.com
as of May 25, 2022 1:34 pm

Features

  • √ ERGONOMIC DESIGN – Designed to be utilized in neutral "handshake" wrist and arm positions for smoother movement and less overall strain, helping alleviate carpal tunnel pain.
  • √ ADJUSTABLE RGB LIGHTING MODE – The trim of the vertical mouse features colorful RGB LEDs with a variety of color options. Select the colors that you prefer using our driver to customize your ergo mouse to your own unique style.
  • √ 5 ADJUSTABLE DPI SETTINGS – Switch between 5 of the available DPI options (800, 1200, 1600, 2400 and 4000) to adjust ergonomic gaming mouse responsiveness depending on your need and/or preference. Featured Optical Tracking Technology helps ensure greater sensitivity for precise tracking on a wide range of surfaces.
  • √ THUMB BUTTONS & REMOVABLE PALM REST – Use the back/forward buttons located near the thumb area for optimum convenience, (button functionality can also be changed and reassigned using our driver or compatible software). This ergonomic vertical mouse also comes included with a palm rest that can be easily detached based on the user's preference and convenience.
  • √ WIDE COMPATIBILITY & FREE LIFETIME SUPPORT – The wired vertical mouse compatible with Windows 7/8/10, XP, Vista 7/8 and Linux etc. All J-Tech Digital Products include a One-Year Manufacturer Warranty and free lifetime technical support from our Customer Support Team located in Houston, Texas - Available M-F 9AM-6PM CST - Contact information available on the J-Tech Digital Seller Page.